Basophils and mast cells have high-affinity receptors for which immunoglobulin?

Basophils and mast cells express high-affinity receptors for immunoglobulin E (IgE). This is crucial for the immune response to allergens and is primarily involved in hypersensitivity reactions. The binding of IgE to these receptors on basophils and mast cells leads to cell activation and the release of mediators such as histamine, which plays a key role in the allergic response.

When an allergen cross-links the IgE bound to these cells, it initiates a cascade of events that can result in symptoms such as itching, swelling, and other allergic manifestations. The high-affinity receptors allow these cells to respond rapidly and effectively to allergens even at low concentrations. This mechanism is central to understanding allergic diseases like asthma, hay fever, and anaphylaxis, where the interaction between allergens and IgE-coated cells is pivotal.