What hexose monophosphate shunt product aids in the detoxification of peroxides in RBCs?

The hexose monophosphate shunt, also known as the pentose phosphate pathway, plays a critical role in the metabolism of glucose and is particularly important in red blood cells (RBCs) for maintaining the integrity and function of these cells. One of the key products of this pathway is NADPH.

NADPH is essential for the detoxification of reactive oxygen species, including hydrogen peroxide (H2O2), which can be harmful to RBCs. This detoxification process involves the conversion of hydrogen peroxide into water, a reaction that is facilitated by the enzyme glutathione peroxidase. In this context, glutathione, which exists in a reduced form (reduced glutathione, or GSH), also plays a vital role in protecting cells from oxidative damage. NADPH is required to maintain the supply of reduced glutathione, thus allowing RBCs to effectively scavenge and neutralize peroxides.

This connection explains why the correct answer includes both NADPH and reduced glutathione, as their combined action enables RBCs to detoxify peroxides effectively and prevent oxidative stress, promoting cellular longevity and function.